2000 Grants

• Role of the Ferroxidase Ceruloplasmin in Iron-Mediated Free Radical Injury in the Substantia Nigra

• Additional Pilot Study Grants Funded in 2000

• Intracellular Signaling by Hydrogen Peroxide Via the Thiol Redoxstate

• Biophysical Approach to the Structural Characterization of Alpha-Synuclein, A Protein Implicated in Parkinson’ Disease

• Role of the Stress-Activated Protein Kinase SPAK/JNK Signaling Pathway in the MPTP-Induced Neuronal Death Model of Parkinson’ Disease

• Glutamateric Compensatory Mechanisms Following Injury to the Basal Ganglia

• Intrinsic Antioxidant Properties of Dopaminergic Neurons

• Role of Alpha-Synuclein in Synaptic Transmission

• Expression of Aromatic Amino Acid Decarboxylase and Vesicular Monomine Transporter Using Lentiviral Vectors to Prevent L-Dopa Induced Dyskinesias

• Central Motor Fatigue in Parkinson’ Disease and the Effect of Levodopa: A transcranial Magnetic Stimulation Study

• Characterization of a Regulated Recombinant Adeno-Associated Viral Vector Encoding Human GDNF for the Treatment of Parkinson’s Disease

• Human Brain Expression of Alpha-Synuclein Messenger RNA in Parkinson’s Disease and Related Diseases

• GABA-B Receptors and Parkinson’s Disease

• Effects of Intermittent vs Coninuous L-DOPA on GABAergic Neurons of the Basal Ganglia

• Parkinson’s Disease and FGF Receptor in Gene Therapy

• Anatomical Subtrates of Parkinsonian Tremor

• Neuromelanin, Iron and Ferritin in Locus Ceruleus as Potential Determinants of Selective Neuronal Vulnerability

• Biochemistry and Immunohistochemistry of Lewy Bodies

• Role of Alpha-Synuclein in Neurotransmitter Secretion

• Oxidative Stress and BDNF Signaling in Dopaminergic Neurons

• In Utero Gram-Negative Bacterial Infections as a Rick Factor for Parkinson’s Disease

• Extracellular Superoxide dismutase in Parkinson’s disease

• Activation of Cell Cycle Machinery Mediates Neuronal Cell Death Following Proteasomal Inhibition in a Cellular Model of Parkinson’s Disease

• A Dopaminergic Cell Line for Transplantation Therapy of PD

• Molecular Chaperones and Huntington’s Disease

• Assessing Postural Rigidity from Quiet Stance in Patients with Parkinson’s Disease.

• Effects of Unilateral Intrastriatal Dopaminergic Grafts in MPTP-Treated Hemiparkinsonian Monkeys

• Caspase Dependent and Independent Pathways for Cell Death Mechanisms

• Transgenic and Knockout Animal Facility

• Neuroprotection of Vesicular Monoamine Transporter in the Pathogenesis of Parkinson’s Disease