Research Insights

Neuropsychological functioning following bilateral subthalamic nucleus stimulation in Parkinson’s disease

Morrison, C.E., Borod, J.C., Perrine, K., Beric, A., Brin, M.F., Rezai, A., Kelly, P., Sterio, D., Germano, I., Weisz, D., & Olanow, C.W. (2003) Neuropsychological functioning following bilateral subthalamic nucleus stimulation in Parkinson’s disease , 41274

Seventeen PD patients were tested before and after bilateral DBS-STN, both on and off stimulation. Eleven matched PD controls were used for comparison. Relative to changes seen in the controls, the surgery for electrode placement mildly adversely affected attention and language functions. STN stimulation, per se, had little effect on cognition. The DBS-STN procedure as a whole resulted in a mild decline in delayed verbal recall and language functions. There were no surgery, stimulation, or procedure effects on depression scale scores.

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