Deep brain stimulation for Parkinson’s disease dissociates mood and motor circuits: a functional MRI case study
Stefurak T, Mikulis D, Mayberg H, Lang AE, Hevenor S, Pahapill P, Saint-Cyr J, & Lozano A Deep brain stimulation for Parkinson’s disease dissociates mood and motor circuits: a functional MRI case study Movement Disorders, 2003 Dec;18(12):1508-16.
This is a case study of a 36-year old woman who underwent bilateral DBS-STN 10 years after motor symptoms began. She had a pre-existing history of recurrent depression (starting at age 12) treated with drug therapy as well as ECT. At the time of her surgery her depression had been in remission for two years. After her surgery, when her left STN was stimulated she experienced decreased tremor and improved motor functioning. When her right STN was stimulated she experienced various emotional disturbances within 30 seconds, which ceased immediately after cessation of the stimulation. The right-sided STN effect was not reproducible after 4 weeks (no stimulation to that side during that time) or after surgical repositioning/revision. This case provides evidence of possible physiological mechanisms to explain depressive symptoms as well as resolution of symptoms in patients undergoing DBS-STN surgery.