Research Insights

Colonic transit time and rectoanal videomanometry in Parkinson’s disease

Sakakibara, R., T. Odaka, et al. (2003) Colonic transit time and rectoanal videomanometry in Parkinson’s disease , 74(2): 268-72

These authors suggest that PD patients have a higher incidence of constipation (over 50%), which may appear earlier than other motor symptoms. They looked at 12 patients with PD (10 men, 2 women, mean age 68, mean duration of PD 5 years) compared to 10 age matched controls. They found that the PD patients had more dif?culties with constipation and defecation and hypothesized that this may be due to chemical changes in the basal ganglia, putamen, globus pallidus, and surrounding nuclei in the brain (all areas in the brain that are affected with PD), which have been found in experimental studies (e.g. animal research). They also suggest that difficulties with poor anal muscle control and weak abdominal muscle strain (e.g. similar to when one coughs) also contribute to defecation dif?culties (control, leakage, and incontinence).

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