Research Insights

Cognitive and behavioural effects of chronic stimulation of the subthalamic nucleus in patients with Parkinson’s disease

Daniele, A., Albanese, A., Contarino, M.F., Zinzi, P., Barbier, A., Gasparini, F., Romito, L.M.A., Bentivoglio, A.R., & Scerrati, M. (2003) Cognitive and behavioural effects of chronic stimulation of the subthalamic nucleus in patients with Parkinson’s disease , 74, 175-182

Motor, cognitive, behavioral, and functional assessments were undertaken in 20 patients with PD before implantation and then at 3, 6, and 12 months afterwards. Nine patients were also examined at 18 months after surgery. On all postoperative assessments, there was an improvement in parkinsonian motor symptoms, quality of life, and activities of daily living while off antiparkinsonian drugs. A significant postoperative decrease in depressive and anxiety symptoms was observed across all assessments for most of the patients. Following implantation, three patients developed transient manic symptoms with hypersexuality.

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