Research Insights

Chronic inhibition of the subthalamic nucleus in Parkinson’s disease

Krause, M., Fogel, W., Mayer, P., Kloss, M., & Tronnier, V. (2004) Chronic inhibition of the subthalamic nucleus in Parkinson’s disease , 219, 119-124

This study examined the effects of DBS-STN in 27 patients. Patients were assessed with the UPDRS before and yearly after surgery. The average follow-up time was 29.8 months (about 2 years). Data were reported for changes in UPDRS scores in four conditions: off-meds/off-stimulation, on-meds/off stimulation, off-meds on stimulation, on-meds/on stimulation. Consistent with other studies, significant improvements in motor functioning was seen in most patients. The UPDRS has one item that assesses speech. In this sample, after surgery when on-medication, speech was improved. However, when off-meds and on stimulation, speech actually worsened.

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