Research Insights

Bilateral subthalamic or pallidal stimulation for Parkinson’s disease affects neither memory nor executive functions: a consecutive series of 62 patients

Ardouin, C., Pillon, B., Peiffer, E., et al. (1999) Bilateral subthalamic or pallidal stimulation for Parkinson’s disease affects neither memory nor executive functions: a consecutive series of 62 patients , 46, 217-223.

The aim of this study was to assess the influence of bilateral stimulation of the STN or internal globus pallidus on cognition and mood in Parkinson’s disease. Sixty-two patients were assessed before and after 3 to 6 months of chronic bilateral stimulation of the subthalamic nucleus (n = 49) or internal globus pallidus (n = 13). There were limited changes in cognition following the surgery. There was a deterioration on a word-generation task. There was also a mild but significant improvement in mood. This article concluded that stimulation of the subthalamic nucleus or internal globus pallidus does not change the overall cognitive performance in Parkinson’s disease.

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