Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson’s disease
Stefani, A., Lozano, AM., Peppe, A., Stanzione, P., Galati, S., Tropepi, D., Pierantozzi, M., Brusa, L., Scarnati, E., & Mazzone, P. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson’s disease , Brain, 2007 Jan 24; [Epub ahead of print]
This study looked at concurrent stimulation of two areas within the brain (subthalamic [STN] and pedunculopontine nuclei [PPN]) to treat symptoms of PD. The authors found that stimulation of the PPN added to benefits of DBS-STN specifically in the areas of gait, postural instability, and increased efficacy of postsurgical medications. The patients were only followed for a short time afterward so long term adverse events are unknown. The only adverse event noted was a parasthesia (unusual feeling, burning, itching, etc.) in the legs at higher stimulation frequencies. Follow up studies from this group are on-going.